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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
31.21
Human Site:
T1279
Identified Species:
49.05
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1279
T
K
T
K
K
Q
T
T
L
A
F
K
P
I
K
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1327
T
R
V
R
K
T
P
T
S
S
G
K
P
S
A
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1313
T
R
V
R
K
T
P
T
S
S
G
K
P
S
A
Dog
Lupus familis
XP_537646
1532
174610
T1279
T
K
T
K
K
Q
T
T
L
P
F
K
P
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
T1275
P
G
A
K
K
Q
T
T
L
P
F
K
P
V
K
Rat
Rattus norvegicus
P41516
1526
173202
T1275
T
R
A
K
K
Q
T
T
L
P
F
K
P
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
T1309
T
K
G
K
K
Q
N
T
L
L
S
K
R
V
K
Chicken
Gallus gallus
O42130
1553
174974
T1283
Q
G
T
K
R
Q
T
T
L
P
F
K
P
I
K
Frog
Xenopus laevis
NP_001082502
1579
178601
T1291
V
K
D
K
K
Q
A
T
L
P
F
K
P
V
K
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
T1289
S
K
S
G
K
Q
T
T
L
T
F
K
P
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
K1196
G
I
N
L
K
T
A
K
A
L
K
G
Q
K
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
N1261
T
G
R
G
P
K
K
N
V
C
T
E
V
L
P
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
A1196
L
W
T
D
D
L
N
A
F
M
A
E
L
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
T1214
K
K
P
A
P
K
K
T
T
K
K
A
S
E
S
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
G1178
Q
R
D
A
E
A
R
G
G
N
V
P
N
K
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
33.3
33.3
93.3
N.A.
66.6
80
N.A.
60
73.3
66.6
60
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
53.3
53.3
93.3
N.A.
73.3
86.6
N.A.
66.6
80
73.3
86.6
N.A.
6.6
N.A.
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
14
0
7
14
7
7
7
7
7
0
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
14
7
7
0
0
0
0
0
0
0
0
7
0
% D
% Glu:
0
0
0
0
7
0
0
0
0
0
0
14
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
47
0
0
0
0
% F
% Gly:
7
20
7
14
0
0
0
7
7
0
14
7
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
0
27
0
% I
% Lys:
7
40
0
47
67
14
14
7
0
7
14
67
0
14
47
% K
% Leu:
7
0
0
7
0
7
0
0
54
14
0
0
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
14
7
0
7
0
0
7
0
0
% N
% Pro:
7
0
7
0
14
0
14
0
0
34
0
7
60
0
7
% P
% Gln:
14
0
0
0
0
54
0
0
0
0
0
0
7
0
7
% Q
% Arg:
0
27
7
14
7
0
7
0
0
0
0
0
7
0
7
% R
% Ser:
7
0
7
0
0
0
0
0
14
14
7
0
7
14
14
% S
% Thr:
47
0
27
0
0
20
40
74
7
7
7
0
0
0
0
% T
% Val:
7
0
14
0
0
0
0
0
7
0
7
0
7
27
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _